Wake up to what matters.

VIVAYZIO® is a once-daily treatment for moderate to severe chronic sleep inertia syndrome (CSIS) in adults.

Professional woman opening curtains to bright morning sunlight, stretching with a peaceful smile

It's more than just being tired.

Chronic sleep inertia syndrome (CSIS) is a real medical condition affecting an estimated 47 million Americans. If you experience prolonged grogginess, impaired alertness upon waking, or reduced morning cognitive function lasting 30 minutes or more after your alarm goes off, you may be living with CSIS.

You deserve mornings that feel like mornings.

Take the CSIS self-assessment
Diverse group of adults looking tired and disoriented in morning setting

Real results, starting as early as Week 2.

In a 24-week, randomized, double-blind, placebo-controlled clinical trial (SUNRISE-1), adults with moderate to severe CSIS who took VIVAYZIO experienced:

73%
reduction in Wake-Onset Cognitive Delay (WOCD) score at Week 12 vs. placebo (p<0.001)
68%
of patients reported "much improved" or "very much improved" on the Patient Global Impression of Change (PGIC) at Week 24
4.2x
faster transition to full alertness compared to placebo
47 min → 11 min
Mean time to functional wakefulness reduced

Individual results may vary.

See full clinical data

Real people. Real mornings.

Sarah, 34, professional woman in business attire
"I used to set five alarms. My husband would have to physically shake me awake. After starting Vivayzio, I wake up on the first alarm. I didn't know mornings could feel like this."
Sarah, 34, Portland, OR
Marcus, 41, professional man in business casual
"My boss thought I was lazy. I thought I was lazy. Turns out, I had CSIS. Vivayzio gave me my career back."
Marcus, 41, Atlanta, GA
Diane, 58, mature woman with warm smile
"I missed my daughter's graduation rehearsal because I couldn't wake up in time. That was the moment I talked to my doctor. I wish I'd done it sooner."
Diane, 58, Scottsdale, AZ

Individual results may vary. These are real patients who have been compensated for their testimonials.

A targeted approach to waking up.

VIVAYZIO® (somniclarin sodium) works by selectively modulating cortical arousal pathways during the sleep-wake transition. Unlike traditional stimulants, Vivayzio does not increase baseline cortisol levels or interfere with natural sleep architecture.

🎯

Targeted

Acts specifically on wake-transition receptors

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Non-stimulant

Not a controlled substance. Not habit-forming.

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Once daily

Taken at bedtime. Works while you sleep so you wake up ready.

Learn more about how Vivayzio works
Scientific diagram showing brain pathways and Vivayzio's mechanism of action

You may pay as little as $0.*

Most commercially insured patients pay as little as $0 per month with the Vivayzio Savings Card. No activation required.

Get your savings card

*Eligibility restrictions apply. Not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. See full terms and conditions.

Happy family enjoying breakfast together, energetic morning scene
IMPORTANT SAFETY INFORMATION: Do not take VIVAYZIO if you have a history of moderate to severe heart disease or are allergic to somniclarin sodium. VIVAYZIO may cause serious side effects including mood changes, cardiovascular events, and parasomnias. Common side effects include headache, dry mouth, and nausea. See full Important Safety Information